The Hilton Cincinnati Netherland Plaza Hotel is located in the heart of downtown Cincinnati, just off of I-75 and I-71 and just 12 miles north of the Cincinnati/Northern Kentucky International Airport. The hotel is located one short block from the renovated Duke Energy Center (formerly the Cinergy Convention Center).The Hilton Cincinnati Netherland Plaza Hotel is located at the corner of 5th & Race Streets in the heart of downtown Cincinnati.

Within five minutes driving distance of the Hilton Cincinnati Netherland Plaza Hotel is Cincinnati Museum Center at Union Terminal, Playhouse in the Park, Music Hall, Devou Park golf, Rookwood Shopping Center, Paramount's Kings Island, Kenwood Towne Center, Crestview Hills Town Center, Argosy Casino, The Beach Waterpark, and Perfect North Ski Slopes.