Holiday Inn Express Fifth Avenue is located Downtown and it is closest to Midtown Manhattan. The distance from La Guardia International Airport (LGA), JFK International Airport (JFK) and Newark International Airport is about 10 miles, 15 miles and30 miles. You can reach the hotel from the airport either by taxi or train.

From North: I-95 or I-87 South to Triboro Bridge. Merge on Fdr Drive South. Take 49th Street Exit 10. Stay straight on 49th Street. Turn left on 2nd Avenue. Turn right onto East 45th Street and go straight. Holiday Inn Express Fifth Avenue is on West 45th Street between 5th and 6th Aves.

From South: Take 1-95 to Exit 16, Lincoln Tunnel. Go through Tunnel. Follow sighns for uptown or north. Left exit onto Dyer Avenue. Turn right on West 40th Street. Turn left on 8th Avenue. Turn right on West 42nd Street. Turn left oh 6th Avenue. Turn right on W. 46th Street. Turn right on Fifth Avenue. Turn right on West 45th Street. Holiday Inn Express Fifth Avenue is at 15 West 45th Street.