Hampton Inn Seaport Financial District is located in the southern Manhattan Seaport area. The hotel is located on Pearl Street between Peck Slip and Frankfurt Streets directly beside the famous Brooklyn Bridge. The hotel is surrounded by some of New York City's best shopping, restaurants, tourist attractions and historical sites while being located in the heart of the nation's financial district.

Hampton Inn Seaport Financial District is within walking distance of PACE University, City Hall, Chinatown, Little Italy, SOHO, Tribeca and Battery Park City, while the Statue of Liberty, Ellis Island and the New York Stock Exchange are just minutes away. The Hampton Inn Seaport Financial District is also conveniently located across the street from a local bus stop and just two blocks south of a major subway hub, connecting hotel guests to the entire city.