The Hampton Inn Cincinnati Eastgate Hotel is located off I-275 Exit 63B at State Route 32 East on the northeast side of Cincinnati, Ohio. The hotel is 20 minutes drive and 18 miles from downtown Cincinnati, Ohio and 28 miles from Greater Cincinnati/Northern KY Airport. The Eastgate Mall, a 40-store shopping mall, is 5 mile west.

The hotel location is convenient to Kings Island, Riverbend Music Center, River Downs Racetrack, Eastfork State Park and Coney Island.