Dana Hotel & Spa Chicago is located in downtown Chicago's river north which is known for hosting the largest concentration of art galleries in the United States outside of Manhattan. Apart from the art galleries there is the Magnificent Mile one of the hottest shopping streets in the United States. Chicago is also home to some of the best restaurants, fantastic theater and exciting nightlife.

Nearby points of interest from the hotel are Sears Tower, Millennium Park, Merchandise Mart, Magnificent Mile / North Michigan Avenue, Wrigley Building, Tribune Tower, Navy Pier, Loop Financial, Theater District, Art Institute of Chicago, Oak Street Beach and Wrigley Field.