At its prime Times Square location, Hotel 41 At Times Square New York is next door to the Nederlander Theatre, home of the musical "Rent", and just steps from Broadway theaters, entertainment and restaurants, Rockefeller Center and Radio City Music Hall.

The Midtown location is also central to network and cable television studios, including MTV, HBO and ABC, banking and financial institutions such as Ernst and Young and publishing houses like Conde' Nast publications.

Some of the Hotel 41 At Times Square New York's neighboring business buildings are CondeNast, Reuters, Viacom, Ernst & Young, New York Times and Bank of America.